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PGS (Preimplantation Genetic Screening)

PGS (Preimplantation Genetic Screening)

PGS is a genetic test used during IVF to screen embryos for chromosomal abnormalities before implantation. This test can identify issues like Down syndrome, Edwards syndrome, or Patau syndrome. PGS is especially useful for couples undergoing IVF, particularly those with a history of recurrent miscarriages or failed IVF cycles. By screening embryos for chromosomal health, PGS improves the chances of a successful pregnancy and healthy baby.

How it works

In PGS, cells are taken from embryos created through IVF, and their DNA is analyzed for chromosomal abnormalities. The embryos are cultured for a few days before biopsy, typically on day 5 (blastocyst stage), and a small sample of cells is removed from the outer layer. These cells are then tested for chromosomal issues. Healthy embryos are selected for transfer into the uterus. PGS helps ensure that only embryos with the correct number of chromosomes are implanted, reducing the risk of genetic conditions and miscarriage.

Benefits

  • Increases the chances of a successful pregnancy by selecting the healthiest embryos.
  • Reduces the risk of chromosomal conditions like Down syndrome, Patau syndrome, and others.
  • Improves IVF success rates by minimizing the risk of implantation failure or miscarriage.
  • Helps older women or those with repeated IVF failures achieve pregnancy.

Procedure

PGS is a genetic test used during IVF to screen embryos for chromosomal abnormalities before implantation. This test can identify issues like Down syndrome, Edwards syndrome, or Patau syndrome. PGS is especially useful for couples undergoing IVF, particularly those with a history of recurrent miscarriages or failed IVF cycles. By screening embryos for chromosomal health, PGS improves the chances of a successful pregnancy and healthy baby.

When is it recommended

  • Women over 35 years of age or those with a history of recurrent miscarriages.
  • Couples with a history of failed IVF cycles.
  • Couples with a known genetic disorder or family history of genetic conditions.
  • Couples undergoing IVF who want to ensure the embryos have normal chromosomes.

Success Rate

PGS can increase the chances of a successful pregnancy by ensuring the transfer of genetically normal embryos. The success rate for IVF with PGS is typically higher than IVF without genetic screening, particularly for women over 35. The overall pregnancy success rate for IVF with PGS can reach up to 50-60%, depending on age and the number of healthy embryos available for transfer.